Advantages and limitations of high insulin positive glucose

HEC technology was first established by Anders (1966). The technology was further studied by DeFronzo et al. (1979) to further improve and promote clinical applications. Currently, it is internationally. Approved gold standard for evaluating insulin resistance.
Advantages: HEC avoids the effects of endogenous insulin deficiency and hypoglycemia on insulin sensitivity by simultaneously injecting exogenous insulin and glucose. Quantitative detection of insulin sensitivity directly by means of precise infusion pump and computer technology. The results are stable and reproducible. At present, any other technique for evaluating insulin sensitivity cannot be compared with it, and it is an indispensable technology for clinical trials of new diabetes drugs.
Limitations: The implementation of this test requires special equipment and skilled technicians. It is expensive and time-consuming. It requires multiple blood samples during the test and is difficult for patients to accept. It is currently only used for scientific research and cannot be applied to the clinic on a large scale. It measures the sensitivity of the body to exogenous insulin and has a problem of bioavailability. In addition, there is no such stable hyperinsulinemia under normal physiological conditions, and hepatic glucose output and non-insulin-dependent glucose utilization dominate the glucose homeostasis in the fasting state. Therefore, fasting insulin is evaluated by HEC. FINS) There are certain differences in sensitivity. HEC combined with isotope tracing and indirect calorimetry can better evaluate insulin sensitivity and glucose metabolism.
Excerpt from: Knowing - Flying Brother talk