The basic principle of detecting insulin sensitivity

HEC is the gold standard for assessing insulin sensitivity, but it is difficult to carry out extensively. In order to meet clinical needs, some methods for indirectly assessing insulin sensitivity have been introduced: MMT, constant rate infusion glucose model and oral glucose tolerance test (OGTT) area under the blood glucose curve/area ratio under the insulin curve. The above indirect evaluation methods have their own advantages and disadvantages, but their essence is related to the changes of blood sugar and insulin dynamics.
Basic principle: There is a hyperbolic relationship between normal human ISI and insulin's acute response to glucose. When insulin sensitivity decreases, insulin secretion must increase significantly in order to maintain normal blood glucose concentration. However, when beta cells no longer continue to secrete high levels of insulin, insulin resistance accompanied by compensatory hyperinsulinemia will be converted to IGT. MMT is a computer simulation of the relationship between blood glucose and insulin kinetic metabolism, and simultaneous calculation of ISI indicating insulin resistance and glucose-independent glucose effect (SG), also known as multiple sampling of veins. Frequently sampled intravenous glucose tolerance test (FSIGT)